Shaanxi Iknow Biotechnology Co., Ltd.

Shaanxi Iknow Biotechnology Co., Ltd.

 

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Home ProductsFolic Acid Derivatives

L 5 Methyltetrahydrofolate CAS 31690-09-2 Levomefolic Acid White to Yellow powder

L 5 Methyltetrahydrofolate CAS 31690-09-2 Levomefolic Acid White to Yellow powder

L 5 Methyltetrahydrofolate CAS 31690-09-2 Levomefolic Acid White to Yellow powder

Product Details:

Place of Origin: China
Brand Name: IKNOW
Certification: SGS,GMP,ISO,Halal,Kosher
Model Number: Iknow-38

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1Kg/Foil Bag
Delivery Time: 2-3 working days
Payment Terms: Western Union, T/T, L/C
Supply Ability: 50KG/Month
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Detailed Product Description
Product: L-5-Methyltetrahydrofolate CAS: 31690-09-2
Color: White To Yellow Powder Grade: 98%
MF: C20H25N7O6 MW: 459.46
Chloride(Cl): ≤0.5% Water(KF): ≤17.0%
Residue On Ignition: ≤0.1% D-5-Methyltetrahydrofolate: ≤1.0% Area
Arsenic (As2O2): ≤1 Ppm Heavy Metals: ≤10 Ppm
Individual Impurity: ≤1.0% Total Impurities (HPLC): ≤2.5%
Packing: 1KG/Foil Bag Storage: 2 Years

Active Pharmaceutical Intermediates L 5 Methyltetrahydrofolate CAS 31690-09-2
 
What is L-5-Methyltetrahydrofolate ?
 
It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
 
Basic Information 
 

Product NameL-5-Methyltetrahydrofolate
Chemical NameLevomefolic Acid
Cas31690-09-2
MFC20H25N7O6
MW459.46
AppearanceWhite to yellow powder 
Assay99%
ApplicationSupplement
Package1Kg /Tin or As per your request
StorageStore in cool and dry places ,keep away from strong light
Shelf life2 years when properly stored

 
 
Specification 
 

Items
Specifications
Results
Appearance
White to yellow powder
White to yellow powder
Assay(HPLC)
95.0%~103.0%
98.60%
Specific Rotation
(C=1.5% in water, 25℃)
+38.0 to +42.0°
+38.5°
Identification
Positive
Complies
Calcium (Anhydrous basis)
7.0~8.5%
7.80%
Chloride(Cl)
≤0.5%
<0.1%
Water(KF)
≤17.0%
10.20%
Residue on ignition
≤0.1%
0.02%
D-5-Methyltetrahydrofolate
≤1.0% area
0.30% area
Arsenic (As2O2)
≤1 ppm
<1ppm
Boron
≤20 ppm
<20ppm
Heavy metals (as Pb)
≤10 ppm
<10ppm
Individual impurity
≤1.0%
<0.21%
Total impurities (HPLC)
≤2.5%
<1.09%
Residual solvent(Ethanol)
≤1000 ppm
<100 ppm
Total plate count
≤100 cfu/g
<10 cfu/g
Yeast & Mold
≤100 cfu/g
<10 cfu/g
Salmonella
Negative
Complies
E. Coil
Negative
Complies
Conclusion
The above items of the product conform to the standard

 
Function
 
1) Diabetic neuropathy.
Early studies show L-Methylfolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.
 
2) Supplementing L-Methylfolate is the clear alternative while pregnant.
Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.
3) Cardiovascular disease and cancer.
L-methylfolate has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.
 

Our Advantage
 
1) Professional Supplier for many years with advanced facility
2) Factory Price with best quantity
3) Accept Custom Order, Avaliable in thickness and package
4) Offer OEM Service
5) Professional Service and on-time delivery
6) Samples Small quantity are available at any time

Contact Details
Shaanxi Iknow Biotechnology Co., Ltd.

Contact Person: Dylan

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