|Place of Origin:||China|
|Minimum Order Quantity:||Negotiable|
|Packaging Details:||1Kg/Foil Bag|
|Delivery Time:||2-3 working days|
|Payment Terms:||Western Union, T/T, L/C|
|Color:||White To Yellow Powder||Grade:||98%|
|Residue On Ignition:||≤0.1%||D-5-Methyltetrahydrofolate:||≤1.0% Area|
|Arsenic (As2O2):||≤1 Ppm||Heavy Metals:||≤10 Ppm|
|Individual Impurity:||≤1.0%||Total Impurities (HPLC):||≤2.5%|
|Packing:||1KG/Foil Bag||Storage:||2 Years|
5 methyltetrahydrofolate calcium,
l methylfolate calcium
Active Pharmaceutical Intermediates L 5 Methyltetrahydrofolate CAS 31690-09-2
What is L-5-Methyltetrahydrofolate ?
It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
|Chemical Name||Levomefolic Acid|
|Appearance||White to yellow powder|
|Package||1Kg /Tin or As per your request|
|Storage||Store in cool and dry places ,keep away from strong light|
|Shelf life||2 years when properly stored|
White to yellow powder
White to yellow powder
(C=1.5% in water, 25℃)
+38.0 to +42.0°
Calcium (Anhydrous basis)
Residue on ignition
Heavy metals (as Pb)
Total impurities (HPLC)
Total plate count
Yeast & Mold
The above items of the product conform to the standard
1) Diabetic neuropathy.
Early studies show L-Methylfolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.
2) Supplementing L-Methylfolate is the clear alternative while pregnant.
Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.
3) Cardiovascular disease and cancer.
L-methylfolate has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.
1) Professional Supplier for many years with advanced facility
2) Factory Price with best quantity
3) Accept Custom Order, Avaliable in thickness and package
4) Offer OEM Service
5) Professional Service and on-time delivery
6) Samples Small quantity are available at any time
Contact Person: Mr. Dylan Li