Shaanxi Iknow Biotechnology Co., Ltd.

Shaanxi Iknow Biotechnology Co., Ltd.

 

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Home ProductsFolic Acid Derivatives

L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1

L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1

    • L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1
    • L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1
  • L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1

    Product Details:

    Place of Origin: China
    Brand Name: IKNOW
    Certification: ISO, SGS
    Model Number: Iknow-37

    Payment & Shipping Terms:

    Minimum Order Quantity: Negotiable
    Price: Negotiable
    Packaging Details: 1kg/tin
    Delivery Time: 2-3 working days
    Payment Terms: T/T, Western Union
    Supply Ability: 50Kg/ per month
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    Detailed Product Description
    Name: Levomefolate Calcium Cas: 151533-2-1
    Appearance: White Powder Assay: 99%
    Standard: Enterprise Standard Use: Dietary Supplement

    L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1

     

    Basic Information 

     

    Product Name Levomefolate calcium
    Chemical Name L-5-Methyltetrahydrofolate calcium,L-5-MTHF-Ca
    Cas 151533-22-1
    MF C20H23CaN7O6
    MW 497.52
    Appearance White powder 
    Assay 99%
    Application Food additives
    Package 1Kg /Tin or As per your request
    Storage Store in cool and dry places ,keep away from strong light
    Shelf life 2 years when properly stored


     
    What is Levomefolate calcium ?
     
    L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
    It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).

     

     

    L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
     
    Specification

     

    Item Specification Test Results
    Appearance White or off-white crystalline powder Conforms
    Identification HNMR,HPLC Conforms
    Specific Rotation[a]25D(C=1.5% in water) USP +45.07°
    Calcium content(on dry basis ) 7.0%~8.5% 7.3%
    D-5-Methylfolate ≤1.0% Conforms
    Water cotent(KF) ≤16.0% 15.68%
    Single impurity ≤1.0% <0.41%
    Total Impurites ≤2.5% 1.45%
    Residual solvent(Ethanol) ≤5000ppm Not detected
    Chloride(CI) ≤0.5% Conforms
    Arsenic(As) ≤1ppm <1ppm
    Heavy metals ≤20ppm <20ppm
    Boron ≤20ppm Conforms
    Total plate count ≤100cfu/g Conforms
    Yeast and Mold ≤100cfu/g Not detected
    Salmonella Negative Conforms
    E.Coli Negative Conforms
    Assay(on dry basis) >98.0% 99.10%

     
    Use
     
    1) Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
    2) Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
    3) As adjuvant therapy for colon cancer, rectal cancer.
    4) Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
    5) For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.

     

     

    L Methyltetrahydrofolate Levomefolate Calcium Salt 99% CAS 151533-22-1

    Our Advantage

     

    1) Professional Supplier for many years with advanced facility
    2) Factory Price with best quantity
    3) Accept Custom Order, Avaliable in thickness and package
    4) Offer OEM Service
    5) Professional Service and on-time delivery
    6) Samples Small quantity are avaliale at any time

    Contact Details
    Shaanxi Iknow Biotechnology Co., Ltd.

    Contact Person: Dylan

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