Shaanxi Iknow Biotechnology Co., Ltd.

Shaanxi Iknow Biotechnology Co., Ltd.

 

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Home ProductsFolic Acid Derivatives

Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay

Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay

    • Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay
    • Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay
    • Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay
  • Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay

    Product Details:

    Place of Origin: China
    Brand Name: IKNOW
    Certification: ISO , SGS
    Model Number: Iknow-38

    Payment & Shipping Terms:

    Minimum Order Quantity: Negotiable
    Price: Negotiable
    Packaging Details: 1 Kg/ tin
    Delivery Time: 2-3 working days
    Payment Terms: T/T, Western Union
    Supply Ability: 50 kg/ per month
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    Detailed Product Description
    Name:: Levomefolic Acid Cas: 31690 09 2
    Color: White Appearance: Powder
    Standard: Enterprise Standard Use: Dietary Supplement
    High Light:

    5 methyltetrahydrofolate calcium

    ,

    l methylfolate calcium

    Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay

     

    L-5-Methyltetrahydrofolate Information

     

    It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
    It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
    L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).

     

    Levomefolic Acid/L-5-Methyltetrahydrofolate/5-Methyl-(6S)-tetrahydrofolic Acid/5-MTHF

    Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay 0

    Cas : 31690-09-2

    MF:C20H25N7O6

    MW:459.46

    Levomefolic Acid 5 MTHF Folic Acid Methylfolate CAS 31690 09 2 99% Assay 1

     

    Specification

     

    Item Specification Test Results
    Appearance White or yellowish powder Conforms
    Identification The retention time of the principle peak in HPLC conforms with that of the stanard Conforms
    Heavy metals ≤20ppm Conforms
    D-isomer ≤1.0% Conforms
    Water content(KF) ≤8.0% 1.75%
    Single impurity ≤1.0% 0.49%
    Total Impurities ≤2.5% 1.14%
    Residual solvents(Ethanol) ≤5000ppm Not detected
    Assay (on dry basis) 97.0%~103.0% 99.1%

     

     

    Use

     

    1) Major depressive disorder

    Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication.

     

    2) Diabetic neuropathy

    Early studies show L-Methylfolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.

     

    3) supplementing L-Methylfolate is the clear alternative while pregnant

    Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.


    4) Cardiovascular disease and cancer

    L-methylfolate has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.

     

    Contact Details
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    Contact Person: Mr. Dylan Li

    Tel: +8615529351706

    Fax: 86-29-6888-9729

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